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细胞&基因治疗?其实是载体治疗!古朵新闻√
发布时间:2019-10-08   点击次数:157次

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病毒和非病毒载体

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图1:1989-2017年间临床实验中所用到的各种载体的个数及占比。(图片来源:The Journal of Gene Medicine)

非病毒载体

ZHIZHITI:

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LUOZHILI:

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病毒载体


图2:近年来,使用慢病毒及腺相关病毒的进行基因/细胞治疗的比例大幅上升。(数据来源:clinical trials)

NIZHUANLUBINGDU:

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MANBINGDU:

XIANGBIZHIXIA,MANBINGDUYINWUYANZHONGDELINCHUANGSHIGUCHUXIANCHENGWEIMUQIANANQUANDEBINGDUZAITIXUANZEZHIYI。MANBINGDUSHUYUNIZHUANLUBINGDUKE,DANYONGYOUBIγ-NIZHUANLUBINGDUGENGWEIFUZADEJIYINZU。LAIYUANSHANGLAISHUO,MANBINGDUFENWEIRENMIANYIQUEXIANBINGDU(HIV-1),HOUMIANYIQUEXIANBINGDU(SIV)HEMACHUANRANXINGPINXUEBINGDU(EIAV)SANZHONG。MUQIANSHIYONGJIAODUODESHILAIYUANYUHIVDEMANBINGDUZAITI。MANBINGDUZAITIJUYOUNENGGANRANFEIFENLIEQIXIBAO、RONGNAWAIYUANXINGMUDEJIYINPIANDUANDA、WENDINGXINGQIANG、MIANYIYUANXINGXIAODENGTEDIAN。DALIANGYANJIUBIAOMING,XIANGDUIQITABINGDUZAITI,MANBINGDUGANRANXIAOLVGAO,GENGRONGYIGANRANYIXIEJIAONANGANRANDEZUZHIHEXIBAO,QIXIAOLVYIBANKEYIDADAO30%-95%YISHANG。XIANGBIYUXIANBINGDUYIJIXIANXIANGGUANBINGDU,MANBINGDURONGLIANGGENGDA,NENGXIEDAIGENGDA、GENGFUZADEJIYINZU,BINGQIEJUYOUZHENGHEZHUANJIYINDAOSUZHUJIYINZUDENENGLISHICHANWUWENDINGHEZHANGQIDEBIAODA。

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XIANXIANGGUANBINGDU:

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海南七星彩CHULEYISHANGLIANGZHONGZHULIUBINGDUZHIWAI,ZAIJIYINZHILIAOLINGYU,XIANBINGDU、RONGLIUBINGDUYEDOUYOUQIYIXIZHIDI,YINPIANFUSUOXIAN,ZAIZHEILIWOMENBUZHANKAITAOLUN。

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