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个完全人造的蛋白质开关,在细胞里活了!
发布时间:2019-07-26   点击次数:135次

科学家们发明了个完全人造的蛋白质开关,它可在活细胞内工作,从而改变甚至征用细胞内复杂的电路。该开关被称为LOCKR。
 
海南七星彩7月24日发表在Nature杂志上的相关论文描述了LOCKR的设计,并演示了该技术的几种实际应用。这项工作是由华盛顿大学(UW)蛋白质设计医学研究所的David Baker和旧金山分校的Hana El Samad率领的生物工程团队完成的。

KEXUEJIAMENBIAOMING,LOCKRKEBEI“BIANCHENG”LAIGAIBIANJIYINBIAODA,ZHONGXINDINGXIANGXIBAOYUNSHU,JIANGJIETEDINGDEDANBAIZHI,BINGKONGZHIDANBAIZHIJIEHEDEXIANGHUZUOYONG。YANJIURENYUANHAILIYONGLOCKRGOUJIANLEXINDESHENGWUDIANLU,QIGONGZUOYUANLILEISIYUZIZHUCHUANGANQI。ZHEIXIEDIANLUJIANCELAIZIXIBAONEIBUHUOWAIBUHUANJINGDEXINHAO,BINGTONGGUOGAIBIANXIBAOZUOCHUFANYING。ZHEILEISIYUHENGWENQIGANYINGHUANJINGWENDUDEFANGSHI,YIDANDADAOSUOXUDEWENDU,JIUHUIYINDAOJIAREHUOLENGQUEXITONGZIDONGGUANBI。

 


一旦被细胞组装起来,新开关长的一侧仅8纳米。这句话这么长,需要超过一亿左右的蛋白来覆盖。

“LIYONGSHEJIDANBAIKONGZHIXIBAODENENGLIKAICHUANGLESHENGWUXUEDEXINjiYUAN,”GAIWENZHANGDEGONGTONGTONGXUNZUOZHE,JIAZHOUDAXUEJIUJINSHANFENXIAODESHENGWUHUAXUEHESHENGWUWULIXUEJIAOSHOUEl-SamadSHUO。“JIUXIANGJICHENGDIANLUCUJINLEJISUANJIXINPIANCHANYEDEBAOZHAYIYANG,ZHEIXIEDUOGONGNENGHEDONGTAIDESHENGWUKAIGUANHENKUAIJIUKEYIJIESUODUIHUOXIBAOXINGWEIDEKONGZHI,ZHONG,KONGZHIWOMENDEJIANKANG。”

海南七星彩LOCKRZAIZIRANJIEMEIYOUXIANGDUIYINGDECUNZAI,TAYUSHENGWUJISHULINGYUDEMEIYIGEGONGJUDOUSHIBUTONGDE,BAOKUOJINDEJISHU,RUGUANGYICHUANXUEHECRISPR。ZHEIXIEJISHUDEQIANSHENSHUYUZIRAN,RANHOUBEIZHONGXINJIAGONGYONGYUSHIYANSHI、GONGYEHUOYIXUE,DANLOCKRSHIPIWANQUANYOURENLEIGOUXIANGHEJIANZAODESHENGWUJISHUGONGJUZHIYI。


海南七星彩该文章的作者包括UW蛋白质设计医学研究所的Bobby Langan和Scott Boyken,以及参与加州大学伯克利分校-加州大学旧金山分校生物工程研究生项目的Andrew Ng。

“MEIGEXIBAODOUZAIDUIHUANJINGZUOCHUFANYING,”LanganSHUO。“XIBAOJIESHOUCIJI,RANHOUBIXUXIANGBANFAJIEJUETA。LIRU,TAMENLIYONGXIBAOXITONGDIAOJIEJIYINBIAODAHUOJIANGJIEDANBAIZHI。”

LanganHETADETONGSHIMENKAISHICHUANGZAOYIZHONGXINDEFANGSHILAIYUZHEIXIEXIBAOXITONGJINXINGJIAOLIUHUZUO。TAMENTONGGUODANBAISHEJILAICHUANGZAOZIZUZHUANGDANBAI,ZHEIZHONGZIZUZHUANGDANBAIZHIZAITIANJIATEDINGDEFENZI“YAOCHI”HOUCAICHENGXIANSHENGWUHUOXING。

ZAIJIAOMUZHONGANZHUANGLOCKR,YANJIUXIAOZUZHENGMINGJIYINGONGCHENGZHENJUNKEYIZAIYANJIURENYUANSHEDINGDESHIJIANDIANJIANGJIETEDINGDEXIBAODANBAI。TONGGUOZHONGXINSHEJIKAIGUAN,TAMENYEZAISHIYANSHIPEIYANGDERENLEIXIBAOZHONGZHENGMINGLETONGYANGDEXIAOGUO。

海南七星彩WEILEBAOCHIJIANKANG,XIBAOBIXUYANGEKONGZHIQISHENGHUAGUOCHENG。JINJINYIGEJIYINDEYICHANGHUODONGHUOCUOWUDANBAIZHIDEJILEIHUIPOHUAIXIBAODEPINGHENG。ZHEIKENENGDAOZHIXIBAOSIWANGSHENZHIAIZHENG。LOCKRWEIKEXUEJIAMENTIGONGLEYIZHONGYUHUOXIBAOXIANGHUZUOYONGDEXINFANGFA。YINCI,TAKEYIWEIAIZHENG、ZISHENMIANYIXINGJIBINGDENGDUOZHONGJIBINGTIGONGXINDELIAOFA。

“LOCKRWEIBIANCHENGXIBAOKAIPILEYIGEQUANXINDEKENENGLINGYU,”NgSHUO。“WOMENXIANZAIGENGDUODISHISHOUDAOXIANGXIANGLIHECHUANGZAOLIDEXIANZHI,ERBUSHIDAZIRANSUONENGJINHUACHUDEDANBAIXIANZHI。”

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