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海南七星彩 > 企业动态 > 细胞如何应对复制压力?原来ATAD5具双重作用

企业动态

细胞如何应对复制压力?原来ATAD5具双重作用
发布时间:2019-12-27   点击次数:32次

DNACUNCHULESHENGMINGXIANXIANGSUOXUDESUOYOUXINXI,ERXIBAOTONGGUODNAFUZHIHEXIBAOFENLIEJIANGZISHENDEYICHUANXINXICHUANDIJILIANGGEZIXIBAO。ZAIDNAFUZHIGUOCHENGZHONG,LAIZIXIBAOWAIHEXIBAONEIYINSUYINQIDEFUZHIYALIKENENGDAOZHIDNAFUZHIDETINGZHIHUOZHEZHONGZHI。RUGUOXIBAOBUNENGSHIDANGYINGDUIZHEIZHONGFENGXIAN,JIUHUIFASHENGRANSETIDUANLIEHEZHONGPAI,CONGERDAOZHIJIYINZUBUWENDING。ZHEIYOUZHUYUJIESHIWEISHENMEDNAFUZHIYALISHIDAOZHIAIZHENGFAZHANDEZHUYAOYINSUZHIYI。

JINGUANXUDUODNAXIUFUDANBAIZAIYALITIAOJIANXIAQIZHEBAOHUHEZHONGQITINGZHIDEFUZHIGUOCHENGDEZUOYONG,DANMUQIANSHANGBUQINGCHU:ZAIDNAFUZHIZHONGQIZHENZHENGZUOYONGDEFUZHITI(replisome)DANBAISHIRUHEYUZHEIXIEDANBAIXIANGHUZUOYONG、JINXINGXIBAOTONGXUNYIQUEBAOZHONGSHIDEDNAFUZHI。

在韩国Ulsan国立科学技术研究院(UNIST)基础科学研究所(IBS)的基因组完整性研究中心主任Kyungjae Myung和Lee Kyoo-young Lee博士的带领下,韩国研究人员揭示了ATAD5除了已知具有防止这种压力的功能外,它还能应对复制压力。尽管已知ATAD5作为肿瘤抑制因子具有维持基因组稳定性和抑制肿瘤发生的作用,但是尚不清楚复制调节蛋白是否也参与复制应激反应。Myung主任解释说:“我们已经确定了复制应激控制的基本机制,这是导致癌症的主要原因。希望我们的工作将有助于癌症治疗的发展。”
 

海南七星彩Kyungjae MyungYANJIUXIAOZUFAXIAN,ATAD5TONGGUOCONGDNASHANGQUCHUHUANZHUANGPCNALAIDIAOJIEPCNAGONGNENG、QUEBAOFUZHIXUNHUANDEWANZHENGJIESHU,PCNASHIDNAJUHEMEIδDEFUZHUDANBAI,ZUOYONGSHIQUEBAOJUHEMEINENGCHIXUHECHENGQIEZAIGONGZUOGUOCHENGZHONGBUHUICONGMOBANSHANGTUOLUO。ATAD5QUESHIDEXIBAOBIAOXIANCHUFUZHIYALIDETEZHENG——LIRUFUZHISUDUMAN。JINGUANATAD5QUESHIYINQIDEZHEIXIEXIBAOFANYINGKENENGSHIYOUYUATAD5DUIPCNADEDIAOJIEHUOXING,DANYANJIURENYUANTUICEATAD5KENENGZAIDIKANGFUZHIYALIFANGMIANJUYOUQITAZUOYONG。 ATAD5DANBAIBENSHENZAIDNAFUZHIGUOCHENGZHONGQIZHEZHONGYAOZUOYONG,YINCISHIYANZHONGJIANSHAOXIBAOZHONGATAD5DELIANGHUIDAOZHIXUDUOYUZHENGCHANGDNAFUZHIXIANGGUANDEYICHANG。YINWEIZAIDNAFUZHIGUOCHENGZHONGYEHUICHANSHENGFUZHIYALI,SUOYIQUFENATAD5QUEFADUIFUZHIYALIHECHANGGUIDNAFUZHIGUOCHENGDEYINGXIANGZHIGUANZHONGYAO。

WEILEKEFUZHEIGEWENTI,YANJIURENYUANSHEJILEYIZHONGSHIYANFANGFA,ZAIFUZHIYALIKAISHISHIYOUDAOATAD5QUESHI。YANJIUFAXIAN,DANGATAD5SHUIPINGJIANGDISHI,XIBAOJIANGWUFAHUIFUYOUYUFUZHIYALIERTINGZHIDEDNAFUZHI,HAIHUIZENGJIAJIYINZUDEBUWENDINGXING,LIRUXIBAONEIRANSETIDUANLIE、XIAOSHUXUEYEZHONGDEWEIHEHUAWANGZHIHONGXIBAO。ZHEIYIWEIZHEATAD5NENGGOUZAIFUZHIYALIXIAHUIFUDNAFUZHIERYOUZHUYUWEICHIJIYINZUWENDINGXING。

CIHOU,TAMENJINXINGSHIYANYICHANMINGATAD5ZHONGXINQIDONGDNAFUZHIDEFENZIJIZHI。YIZHIRAD51DUIYINFUZHIYALIERTINGZHIDEFUZHIWEIDIANDEJIEGOUBIANHUAHEWENDINGXINGQIGUANJIANZUOYONG。YANJIURENYUANFAXIAN,ATAD5TONGGUOZHIJIEDEDANBAIZHI-DANBAIZHIXIANGHUZUOYONGERCUJINRAD51MUJIDAOTINGZHIDEFUZHIWEIDIANZHOUWEI。

CIWAI,YANJIURENYUANHAIBAOGAOSHUO,ATAD5XIEZAIPCNASHIYOUXIAOZHENGMURAD51DEXIANJUETIAOJIAN。ZHEIXIEBIAOMING,CONGRAD51MUJIKAISHIBINGDAOZHIJIEGOUBIANHUA,DUANLIEHEZUIZHONGFUZHIZHONGQIDEYIXILIEGUOCHENGJUNSHOUATAD5DEDIAOKONG。ZHEIXIEFAXIANTUCHUBIAOMING,ATAD5ZAIWEICHIJIYINZUWENDINGXINGFANGMIANDEZUOYONGCHAOCHULEQIZAIZHENGCHANGDNAFUZHIGUOCHENGZHONGXIEZAIPCNADEZUOYONG。ZHEIXIANGYANJIUDEDIYIZUOZHESu Hyung ParkBOSHIZHICHU:“ZAIXUDUOAIXIBAOZHONGJINGCHANGFAXIANATAD5JIYINDETUBIAN。ZHEIXIANGYANJIUYOUZHUYULIJIEATAD5TUBIANDAOZHIZHONGLIUXINGCHENGDEYUANYIN。”

FUZHIYALIKENENGSHIYOUXIBAOWAILAIYUAN(RUZHIAIJIYINHEHUAXUEWUZHI)YINQIDE。DANSHI,ZUIJINDEYANJIUBIAOMING,XIBAONEIYUANXINGYINSU,LIRUDNATEYIXINGJIEGOUHUOTEDINGDANBAIDEYICHANGGONGNENG,YEKENENGYINQIFUZHIYALI。ZHEIXIANGYANJIUYOUZHUYUJINYIBUSHENRULIJIEXIBAOYINGDUIFUZHIYALIDECHUSHIFANYING,HAITIGONGLEYIZHONGXINDEGAINIANXINGJINZHAN,JIDANBAIZHIKEYIZAIKONGZHIFUZHIYALIZHONGFAHUISHUANGZHONGZUOYONG:XIANFAZHIRENDEYUFANGHEFUZHIYALIDEJIEJUE。ZHEIXIANGYANJIUDETONGXUNZUOZHEKyoo-young LeeBOSHISHUO:“JIANGLAI,WOMENJIANGYANJIUNEIBUYINSURUHEDAOZHIFUZHIYALI,YIJIXIBAORUHEXUANZEXINGDISHIBIEBINGYINGDUIBUTONGDEYALIYUAN。”

 

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